GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic capacity in mouse seminiferous tubules
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چکیده
منابع مشابه
O-6: Maturation of Spermatogenic Cells in Artificial Seminiferous Tubules
Background This study aimed to investigate whether Artificial Seminiferous Tubules (AST) coated with testicular extra cellular matrix (ECM) support maturation of spermatogenic cells from immature testes. MaterialsAndMethods Medical grade tubes coated with testicular ECM were used. Testes from immature mice were loaded in the concentration of 10000- 20000/ml. Tubes were then immersed in germ cel...
متن کاملDifferentiation of human umbilical cord mesenchymal stem cells into germ-like cells in mouse seminiferous tubules
Our previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy endogenous spermatogenesis. Bromodeoxyuridine labeling studies demonstrated that ...
متن کاملLocalization of the DAZ gene expression in seminiferous tubules of patients with spermatogenic disorders.
The research on the expression and mutations of DAZ and its homologues in human and other mammals suggests that protein products of these genes can mainly affect development of germinal cells. The aim of the present study was to analyze the expression of the DAZ gene in seminiferous tubules of six men with spermatogenic disorders (hypospermatogenesis and spermatogenic arrest). The results based...
متن کاملP-98: Ultrastructural Study of Basement Membrane of Seminiferous Tubules in Adult Diabetic Rats with Spermatogenic Alterations
Background: The complications of diabetes are the major problems that occur in diabetic patients. It has been reported that, insulin insufficiency and the impairment of regulatory action of this hormone on Leydig and Sertoli cells have an important role in testicular alterations. Testicular disorders and change in normal spermatogenesis is one of the consequences of diabetes. This study was des...
متن کاملCell-cycle-dependent Colonization of Mouse Spermatogonial Stem Cells After Transplantation into Seminiferous Tubules
Spermatogonial stem cells (SSCs) migrate to the niche upon introduction into the seminiferous tubules of the testis of infertile animals. However, only 5-10% of the transplanted cells colonize recipient testes. In this study, we analyzed the impact of cell cycle on spermatogonial transplantation. We used fluorescent ubiquitination-based cell cycle indicator transgenic mice to examine the influe...
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ژورنال
عنوان ژورنال: BMC Cell Biology
سال: 2009
ISSN: 1471-2121
DOI: 10.1186/1471-2121-10-25